FMN2 Makes Perinuclear Actin to Protect Nuclei during Confined Migration and Promote Metastasis.

ABSTRACT: Cell migration in confined 3D tissue microenvironments is critical for both normal physiological functions and dissemination of tumor cells. We discovered a cytoskeletal structure that prevents damage to the nucleus during migration in confined microenvironments. The formin-family actin filament nucleator FMN2 associates with and generates a perinuclear actin/focal adhesion (FA) system that is distinct from previously characterized actin/FA structures. This system controls nuclear shape and positioning in cells migrating on 2D surfaces. In confined 3D microenvironments, FMN2 promotes cell survival by limiting nuclear envelope damage and DNA double-strand breaks. We found that FMN2 is upregulated in human melanomas and showed that disruption of FMN2 in mouse melanoma cells inhibits their ex

SUBMITTER: Skau CT 

PROVIDER: S-EPMC5135586 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature