Association between Vitamin D Deficiency and Antinuclear Antibodies in Middle-Aged and Older U.S. Adults.

ABSTRACT:

Background

Vitamin D deficiency is associated with cancer and autoimmune diseases, but little is known about the association between vitamin D and antinuclear antibodies (ANA), a biomarker of immune dysfunction in healthy populations. The objective of this study was to determine whether vitamin D deficiency is associated with ANA in middle-aged and older U.S. adults.

Methods

A cross-sectional analysis using the National Health and Nutrition Examination Survey (NHANES) 2001-2004 was conducted. Data were available for 1,012 adults aged 50 years and older. Serum 25-hydroxyvitamin D levels were measured by radioimmunoassay. ANA was measured in a 1:80 dilution of sera by immunofluorescence using HEp-2 cells (seropositive = 3 or 4+).

Results

Greater vitamin D deficiency was

SUBMITTER: Meier HC 

PROVIDER: S-EPMC5135624 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature