Sub-synaptic localization of Ca_v3.1 T-type calcium channels in the thalamus of normal and parkinsonian monkeys.

ABSTRACT: T-type calcium channels (Ca_v3) are key mediators of thalamic bursting activity, but also regulate single cells excitability, dendritic integration, synaptic strength and transmitter release. These functions are strongly influenced by the subcellular and subsynaptic localization of Ca_v3 channels along the somatodendritic domain of thalamic cells. In Parkinson's disease, T-type calcium channels dysfunction in the basal ganglia-receiving thalamic nuclei likely contributes to pathological thalamic bursting activity. In this study, we analyzed the cellular, subcellular, and subsynaptic localization of the Ca_v3.1 channel in the ventral anterior (VA) and centromedian/parafascicular (CM/Pf) thalamic nuclei, the main thalamic targets of basal ganglia output, in norm

SUBMITTER: Chen E 

PROVIDER: S-EPMC5135628 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature