Inflammation Triggers Zeb1-Dependent Escape from Tumor Latency.

ABSTRACT: The emergence of metastatic disease in cancer patients many years or decades after initial successful treatment of primary tumors is well documented but poorly understood at the molecular level. Recent studies have begun exploring the cell-intrinsic programs, causing disseminated tumor cells to enter latency and the cellular signals in the surrounding nonpermissive tissue microenvironment that maintain the latent state. However, relatively little is known about the mechanisms that enable disseminated tumor cells to escape cancer dormancy or tumor latency. We describe here an in vivo model of solitary metastatic latency in the lung parenchyma. The induction of a localized inflammation in the lungs, initiated by lipopolysaccharide treatment, triggers the awakening of these cells, which devel

SUBMITTER: De Cock JM 

PROVIDER: S-EPMC5135644 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature