Noninvasive markers for staging fibrosis in chronic delta hepatitis.

ABSTRACT:

Background

Serum fibrosis markers are useful in staging chronic hepatitis B (HBV) and C (HCV) virus but have not been evaluated in chronic hepatitis D virus (HDV).

Aim

To evaluate the utility of serum fibrosis markers [fibrosis-4 score (FIB-4), aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio, aspartate aminotransferase ratio (AAR), age-platelet index (API), AST-to-platelet-ratio-index (APRI) and Hui score] in HDV infection.

Methods

Clinical and histologic laboratory data from HBV, HCV and HDV patients were evaluated and serum fibrosis markers were calculated. The ability of fibrosis markers to detect advanced fibrosis (Ishak ≥4) and cirrhosis (Ishak = 6) were evaluated and compared between viral infections.

Results

A total of 1003 subje

SUBMITTER: Takyar V 

PROVIDER: S-EPMC5135658 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature