Dendritic Cell KLF2 Expression Regulates T Cell Activation and Proatherogenic Immune Responses.

ABSTRACT: Dendritic cells (DCs) have been implicated as important regulators of innate and adaptive inflammation in many diseases, including atherosclerosis. However, the molecular mechanisms by which DCs mitigate or promote inflammatory pathogenesis are only partially understood. Previous studies have shown an important anti-inflammatory role for the transcription factor Krüppel-like factor 2 (KLF2) in regulating activation of various cell types that participate in atherosclerotic lesion development, including endothelial cells, macrophages, and T cells. We used a pan-DC, CD11c-specific cre-lox gene knockout mouse model to assess the role of KLF2 in DC activation, function, and control of inflammation in the context of hypercholesterolemia and atherosclerosis. We found that KLF2 deficiency enhanced

SUBMITTER: Alberts-Grill N 

PROVIDER: S-EPMC5136303 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature