Female cancer survivors exposed to alkylating-agent chemotherapy have unique reproductive hormone profiles.

ABSTRACT:

Objective

To evaluate reproductive hormone patterns in women exposed to alkylating-agent chemotherapy.

Design

Prospective cohort.

Setting

University hospital.

Patient(s)

Normally menstruating mid-reproductive-age women (20-35 years old) who had previously been exposed to alkylating-agent chemotherapy for cancer treatment were compared with two healthy control populations: similarly-aged women and late-reproductive-age women (43-50 years old).

Intervention(s)

Subjects collected daily urine samples for one cycle.

Main outcome measure(s)

Integrated urinary pregnanediol glucuronide (PDG) and estrone conjugate (E1c) and urinary excretion of gonadotropins (FSH and LH).

Result(s)

Thirty-eight women (13 survivors, 11 same-age control subjects, 14 l

SUBMITTER: Johnson L 

PROVIDER: S-EPMC5136317 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature