Chronic sleep deprivation differentially affects short and long-term operant memory in Aplysia.

ABSTRACT: The induction, formation and maintenance of memory represent dynamic processes modulated by multiple factors including the circadian clock and sleep. Chronic sleep restriction has become common in modern society due to occupational and social demands. Given the impact of cognitive impairments associated with sleep deprivation, there is a vital need for a simple animal model in which to study the interactions between chronic sleep deprivation and memory. We used the marine mollusk Aplysia californica, with its simple nervous system, nocturnal sleep pattern and well-characterized learning paradigms, to assess the effects of two chronic sleep restriction paradigms on short-term (STM) and long-term (LTM) associative memory. The effects of sleep deprivation on memory were evaluated using the op

SUBMITTER: Krishnan HC 

PROVIDER: S-EPMC5136466 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature