PTPN22 Is a Critical Regulator of Fcγ Receptor-Mediated Neutrophil Activation.

ABSTRACT: Neutrophils act as a first line of defense against bacterial and fungal infections, but they are also important effectors of acute and chronic inflammation. Genome-wide association studies have established that the gene encoding the protein tyrosine phosphatase nonreceptor 22 (PTPN22) makes an important contribution to susceptibility to autoimmune disease, notably rheumatoid arthritis. Although PTPN22 is most highly expressed in neutrophils, its function in these cells remains poorly characterized. We show in this article that neutrophil effector functions, including adhesion, production of reactive oxygen species, and degranulation induced by immobilized immune complexes, were reduced in Ptpn22^-/- neutrophils. Tyrosine phosphorylation of Lyn and Syk was altered in Ptpn22^-/

SUBMITTER: Vermeren S 

PROVIDER: S-EPMC5136470 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature