Incomplete and delayed Sox2 deletion defines residual ear neurosensory development and maintenance.

ABSTRACT: The role of Sox2 in neurosensory development is not yet fully understood. Using mice with conditional Islet1-cre mediated deletion of Sox2, we explored the function of Sox2 in neurosensory development in a model with limited cell type diversification, the inner ear. In Sox2 conditional mutants, neurons initially appear to form normally, whereas late- differentiating neurons of the cochlear apex never form. Variable numbers of hair cells differentiate in the utricle, saccule, and cochlear base but sensory epithelium formation is completely absent in the apex and all three cristae of the semicircular canal ampullae. Hair cells differentiate only in sensory epithelia known or proposed to have a lineage relationship of neurons and hair cells. All initially formed neurons lacking hair cell targ

SUBMITTER: Dvorakova M 

PROVIDER: S-EPMC5137136 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature