Submillimetre Network Formation by Light-induced Hybridization of Zeptomole-level DNA.

ABSTRACT: Macroscopic unique self-assembled structures are produced via double-stranded DNA formation (hybridization) as a specific binding essential in biological systems. However, a large amount of complementary DNA molecules are usually required to form an optically observable structure via natural hybridization, and the detection of small amounts of DNA less than femtomole requires complex and time-consuming procedures. Here, we demonstrate the laser-induced acceleration of hybridization between zeptomole-level DNA and DNA-modified nanoparticles (NPs), resulting in the assembly of a submillimetre network-like structure at the desired position with a dramatic spectral modulation within several minutes. The gradual enhancement of light-induced force and convection facilitated the two-dimensional n

SUBMITTER: Iida T 

PROVIDER: S-EPMC5137144 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature