Basigin can be a therapeutic target to restore the retinal vascular barrier function in the mouse model of diabetic retinopathy.

ABSTRACT: Despite the advance in medical technology, diabetic retinopathy (DR) is still an intractable disease which leads to the damage of retinal cells and finally the visual loss. Impairment of retinal vascular barrier triggered by an admixture of multiple inflammatory cytokines is a core of pathophysiology of DR. Therefore, the molecules involved commonly in multiple cytokines-induced impairment of vascular barrier would be the targets of curative treatment of DR. Here, we demonstrate that basigin, a transmembrane molecule expressed in neural barrier-forming endothelial cells, is the molecule essential for vascular barrier impairment which is shared by various triggers including VEGF, TNFα and IL-1β. In vitro data with neural microvascular endothelial cells indicated that stimulation with cytoki

SUBMITTER: Arima M 

PROVIDER: S-EPMC5137162 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature