Effect of Early Adversity and Childhood Internalizing Symptoms on Brain Structure in Young Men.

ABSTRACT:

Importance

Early adversity is an important risk factor that relates to internalizing symptoms and altered brain structure.

Objective

To assess the direct effects of early adversity and child internalizing symptoms (ie, depression, anxiety) on cortical gray matter (GM) volume, as well as the extent to which early adversity associates with variation in cortical GM volume indirectly via increased levels of internalizing symptoms.

Design, setting, and participants

A prospective investigation of associations between adversity within the first 6 years of life, internalizing symptoms during childhood and early adolescence, and altered brain structure in late adolescence (age, 18-21 years) was conducted in a community-based birth cohort in England (Avon Longitudinal Study of

SUBMITTER: Jensen SK 

PROVIDER: S-EPMC5137198 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature