Integration of a radiation biomarker into modeling of thyroid carcinogenesis and post-Chernobyl risk assessment.

ABSTRACT: Strong evidence for the statistical association between radiation exposure and disease has been produced for thyroid cancer by epidemiological studies after the Chernobyl accident. However, limitations of the epidemiological approach in order to explore health risks especially at low doses of radiation appear obvious. Statistical fluctuations due to small case numbers dominate the uncertainty of risk estimates. Molecular radiation markers have been searched extensively to separate radiation-induced cancer cases from sporadic cases. The overexpression of the CLIP2 gene is the most promising of these markers. It was found in the majority of papillary thyroid cancers (PTCs) from young patients included in the Chernobyl tissue bank. Motivated by the CLIP2 findings we propose a mechanistic mode

SUBMITTER: Kaiser JC 

PROVIDER: S-EPMC5137265 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature