Exploring experimental cerebral malaria pathogenesis through the characterisation of host-derived plasma microparticle protein content.

ABSTRACT: Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection responsible for thousands of deaths in children in sub-Saharan Africa. CM pathogenesis remains incompletely understood but a number of effectors have been proposed, including plasma microparticles (MP). MP numbers are increased in CM patients' circulation and, in the mouse model, they can be localised within inflamed vessels, suggesting their involvement in vascular damage. In the present work we define, for the first time, the protein cargo of MP during experimental cerebral malaria (ECM) with the overarching hypothesis that this characterisation could help understand CM pathogenesis. Using qualitative and quantitative high-throughput proteomics we compared MP proteins from non-infected and P. berghei ANKA-i

SUBMITTER: Tiberti N 

PROVIDER: S-EPMC5137300 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature