Differential cytokine sensitivities of STAT5-dependent enhancers rely on Stat5 autoregulation.

ABSTRACT: Cytokines utilize the transcription factor STAT5 to control cell-specific genes at a larger scale than universal genes, with a mechanistic explanation yet to be supplied. Genome-wide studies have identified putative STAT5-based mammary-specific and universal enhancers, an opportunity to investigate mechanisms underlying their differential response to cytokines. We have now interrogated the integrity and function of both categories of regulatory elements using biological and genetic approaches. During lactation, STAT5 occupies mammary-specific and universal cytokine-responsive elements. Following lactation, prolactin levels decline and mammary-specific STAT5-dependent enhancers are decommissioned within 24 h, while universal regulatory complexes remain intact. These differential sensitiviti

SUBMITTER: Willi M 

PROVIDER: S-EPMC5137441 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature