Chemoprevention of colorectal cancer in individuals with previous colorectal neoplasia: systematic review and network meta-analysis.

ABSTRACT:

Objective

 To assess the comparative efficacy and safety of candidate agents (low and high dose aspirin, non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs), calcium, vitamin D, folic acid, alone or in combination) for prevention of advanced metachronous neoplasia (that is, occurring at different times after resection of initial neoplasia) in individuals with previous colorectal neoplasia, through a systematic review and network meta-analysis.

Data sources

 Medline, Embase, Web of Science, from inception to 15 October 2015; clinical trial registries.

Study selection

 Randomized controlled trials in adults with previous colorectal neoplasia, treated with candidate chemoprevention agents, and compared with placebo or another candidate agent. Primary efficacy outc

SUBMITTER: Dulai PS 

PROVIDER: S-EPMC5137632 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature