Determinants of hepatotoxicity after repeated supratherapeutic paracetamol ingestion: systematic review of reported cases.

ABSTRACT:

Aims

To evaluate the role of reported daily dose, age and other risk factors, and to assess the value of quantifying serum transaminase activity and paracetamol (acetaminophen) concentration at initial assessment for identifying patients at risk of hepatotoxicity following repeated supratherapeutic paracetamol ingestion (RSPI).

Methods

Systematic literature review with collation and analysis of individual-level data from reported cases of RSPI associated with liver damage.

Results

In 199 cases meeting the selection criteria, severe liver damage (ALT/AST ≥1000 IU l(-1) , liver failure or death) was reported in 186 (93%) cases including 77/78 (99%) children aged ≤6 years. Liver failure occurred in 127 (64%) cases; of these 49 (39%) died. Maximum ingested daily paracetam

SUBMITTER: Acheampong P 

PROVIDER: S-EPMC5137817 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature