Limited sampling strategy for determining metformin area under the plasma concentration-time curve.

ABSTRACT:

Aim

The aim was to develop and validate limited sampling strategy (LSS) models to predict the area under the plasma concentration-time curve (AUC) for metformin.

Methods

Metformin plasma concentrations (n = 627) at 0-24 h after a single 500 mg dose were used for LSS development, based on all subsets linear regression analysis. The LSS-derived AUC(0,24 h) was compared with the parameter 'best estimate' obtained by non-compartmental analysis using all plasma concentration data points. Correlation between the LSS-derived and the best estimated AUC(0,24 h) (r(2) ), bias and precision of the LSS estimates were quantified. The LSS models were validated in independent cohorts.

Results

A two-point (3 h and 10 h) regression equation with no intercept estimated accurately the i

SUBMITTER: Santoro AB 

PROVIDER: S-EPMC5137825 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature