Conducting polymer-based multilayer films for instructive biomaterial coatings.

ABSTRACT:

Aim

To demonstrate the design, fabrication and testing of conformable conducting biomaterials that encourage cell alignment.

Materials & methods

Thin conducting composite biomaterials based on multilayer films of poly(3.4-ethylenedioxythiophene) derivatives, chitosan and gelatin were prepared in a layer-by-layer fashion. Fibroblasts were observed with fluorescence microscopy and their alignment (relative to the dipping direction and direction of electrical current passed through the films) was determined using ImageJ.

Results

Fibroblasts adhered to and proliferated on the films. Fibroblasts aligned with the dipping direction used during film preparation and this was enhanced by a DC current.

Conclusion

We report the preparation of conducting polymer-based films

SUBMITTER: Hardy JG 

PROVIDER: S-EPMC5137882 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature