Reconstruction of Transcription Control Networks in Mollicutes by High-Throughput Identification of Promoters.

ABSTRACT: Bacteria of the class Mollicutes have significantly reduced genomes and gene expression control systems. They are also efficient pathogens that can colonize a broad range of hosts including plants and animals. Despite their simplicity, Mollicutes demonstrate complex transcriptional responses to various conditions, which contradicts their reduction in gene expression regulation mechanisms. We analyzed the conservation and distribution of transcription regulators across the 50 Mollicutes species. The majority of the transcription factors regulate transport and metabolism, and there are four transcription factors that demonstrate significant conservation across the analyzed bacteria. These factors include repressors of chaperone HrcA, cell cycle regulator MraZ and two regulators with unclear

SUBMITTER: Fisunov GY 

PROVIDER: S-EPMC5138195 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature