Cardiac inotropy, lusitropy, and Ca²⁺ handling with major metabolic substrates in rat heart.

ABSTRACT: Fatty acid (FA)-dependent oxidation is the predominant process for energy supply in normal heart. Impaired FA metabolism and metabolic insufficiency underlie the failing of the myocardium. So far, FA metabolism in normal cardiac physiology and heart failure remains undetermined. Here, we evaluate the mechanisms of FA and major metabolic substrates (termed NF) on the contraction, relaxation, and Ca²⁺ handling in rat left ventricular (LV) myocytes. Our results showed that NF significantly increased myocyte contraction and facilitated relaxation. Moreover, NF increased the amplitudes of diastolic and systolic Ca²⁺ transients ([Ca²⁺]_i), abbreviated time constant of [Ca²⁺]_i decay (tau), and prolonged the peak duration of [Ca

SUBMITTER: Zhao ZH 

PROVIDER: S-EPMC5138277 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature