Correlations Between Changes in Undercarboxylated Osteocalcin and Muscle Function in Hypoparathyroidism.

ABSTRACT:

Background

Muscles and bones are interconnected. Recent studies suggest that undercarboxylated osteocalcin from bone may affect muscle mass and strength. There are, however, no prospective human data on this relationship.

Methods

We previously treated patients with hypoparathyroidism with intact Parathyroid Hormone (PTH) or placebo in a six-month randomized, placebo-controlled trial and demonstrated a marked increase in undercarboxylated osteocalcin (ucOC) in the PTH-treated group. We therefore investigated if this increase correlated with changes in muscle mass, strength or function. Primarily, the muscle mass using Dual energy X-ray Absorptiometry (DXA) was measured and the maximal voluntary isometric muscle strength at the upper and lower extremities, using dynamometry, w

SUBMITTER: Harslof T 

PROVIDER: S-EPMC5138377 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature