Comparison of 432 Pseudomonas strains through integration of genomic, functional, metabolic and expression data.

ABSTRACT: Pseudomonas is a highly versatile genus containing species that can be harmful to humans and plants while others are widely used for bioengineering and bioremediation. We analysed 432 sequenced Pseudomonas strains by integrating results from a large scale functional comparison using protein domains with data from six metabolic models, nearly a thousand transcriptome measurements and four large scale transposon mutagenesis experiments. Through heterogeneous data integration we linked gene essentiality, persistence and expression variability. The pan-genome of Pseudomonas is closed indicating a limited role of horizontal gene transfer in the evolutionary history of this genus. A large fraction of essential genes are highly persistent, still non essential genes represent a considerable fracti

SUBMITTER: Koehorst JJ 

PROVIDER: S-EPMC5138606 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature