DETC-based bacterial cellulose bio-curatives for topical treatment of cutaneous leishmaniasis.

ABSTRACT: The treatment of leishmaniasis still relies on drugs with potentially serious adverse effects. Herein, we tested a topical formulation of bacterial cellulose (BC) membranes containing Diethyldithiocarbamate (DETC), a superoxide dismutase 1 inhibitor. Leishmania-infected macrophages exposed to BC-DETC resulted in parasite killing, without pronounced toxic effects to host cells. This outcome was associated with lower SOD1 activity and higher production of superoxide and cytokine mediators. Topical application of BC-DETC significantly decreased lesion size, parasite load and the inflammatory response at the infection site, as well as the production of both IFN-γ and TNF. Combination of topical BC-DETC plus intraperitoneal Sb^v also significantly reduced disease development and paras

SUBMITTER: Celes FS 

PROVIDER: S-EPMC5138610 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature