In-situ particles reorientation during magnetic hyperthermia application: Shape matters twice.

ABSTRACT: Promising advances in nanomedicine such as magnetic hyperthermia rely on a precise control of the nanoparticle performance in the cellular environment. This constitutes a huge research challenge due to difficulties for achieving a remote control within the human body. Here we report on the significant double role of the shape of ellipsoidal magnetic nanoparticles (nanorods) subjected to an external AC magnetic field: first, the heat release is increased due to the additional shape anisotropy; second, the rods dynamically reorientate in the orthogonal direction to the AC field direction. Importantly, the heating performance and the directional orientation occur in synergy and can be easily controlled by changing the AC field treatment duration, thus opening the pathway to combined hyperther

SUBMITTER: Simeonidis K 

PROVIDER: S-EPMC5138615 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature