Epigenome-wide association data implicates DNA methylation-mediated genetic risk in psoriasis.

ABSTRACT:

Background

Psoriasis is a chronic inflammatory skin disease characterized by epidermal hyperproliferation and altered keratinocyte differentiation and inflammation and is caused by the interplay of genetic and environmental factors. Previous studies have revealed that DNA methylation (DNAm) and genetic makers are closely associated with psoriasis, and strong evidences have shown that DNAm can be controlled by genetic factors, which attracted us to evaluate the relationship among DNAm, genetic makers, and disease status.

Methods

We utilized the genome-wide methylation data of psoriatic skin (PP, N = 114) and unaffected control skin (NN, N = 62) tissue samples in our previous study, and we performed whole-genome genotyping with peripheral blood of the same sample

SUBMITTER: Zhou F 

PROVIDER: S-EPMC5139011 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature