Perioperative statin therapy in cardiac surgery: a meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Several studies suggest beneficial effects of perioperative statin therapy on postoperative outcome after cardiac surgery. However, recent randomized controlled trials (RCTs) show potential detrimental effects. The objective of this systematic review is to examine the association between perioperative statin therapy and clinical outcomes in cardiac surgery patients.

Methods

Electronic databases were searched up to 1 November 2016 for RCTs of preoperative statin therapy versus placebo or no treatment in adult cardiac surgery. Postoperative outcomes were acute kidney injury, atrial fibrillation, myocardial infarction, stroke, infections, and mortality. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using fixed-effects meta-analyses. Primary analy

SUBMITTER: Putzu A 

PROVIDER: S-EPMC5139027 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature