The psoriasis-associated deletion of late cornified envelope genes LCE3B and LCE3C has been maintained under balancing selection since Human Denisovan divergence.

ABSTRACT:

Background

A common, 32kb deletion of LCE3B and LCE3C genes is strongly associated with psoriasis. We recently found that this deletion is ancient, predating Human-Denisovan divergence. However, it was not clear why negative selection has not removed this deletion from the population.

Results

Here, we show that the haplotype block that harbors the deletion (i) retains high allele frequency among extant and ancient human populations; (ii) harbors unusually high nucleotide variation (π, P < 4.1 × 10^-3); (iii) contains an excess of intermediate frequency variants (Tajima's D, P < 3.9 × 10^-3); and (iv) has an unusually long time to coalescence to the most recent common ancestor (TSel, 0.1 quantile).

Conclusions

Our results are most parsimonious with

SUBMITTER: Pajic P 

PROVIDER: S-EPMC5139038 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature