MicroRNA-27a rs895819 is associated with obesity in HIV infected preeclamptic Black South African women on HAART.

ABSTRACT:

Background

Preeclampsia (PE) and HIV/AIDS present a major health challenge globally. South Africa has the highest disease burden of both HIV/AIDS and PE in the world. Despite extensive research, the pathophysiology of these conditions is not completely understood, however a genetic predisposition in women may affect susceptibility. MiRNA-27a regulates adipogenesis and glucose metabolism. A single nucleotide polymorphism (SNP) in miRNA-27a (rs895819T > C) has shown to have disparate effects in various populations. This study investigated the frequency of rs895819 in pregnant normotensive and preeclamptic Black South African (SA) women.

Methods

Enrollment into the study included: normotensive (n = 95; 45 HIV+; 80 analysed for rs895819T > C, age range: 16-46 years) and PE patie

SUBMITTER: Maharaj NR 

PROVIDER: S-EPMC5139039 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature