Cystic fibrosis lung environment and Pseudomonas aeruginosa infection.

ABSTRACT:

Background

The airways of patients with cystic fibrosis (CF) are highly complex, subject to various environmental conditions as well as a distinct microbiota. Pseudomonas aeruginosa is recognized as one of the most important pulmonary pathogens and the predominant cause of morbidity and mortality in CF. A multifarious interplay between the host, pathogens, microbiota, and the environment shapes the course of the disease. There have been several excellent reviews detailing CF pathology, Pseudomonas and the role of environment in CF but only a few reviews connect these entities with regards to influence on the overall course of the disease. A holistic understanding of contributing factors is pertinent to inform new research and therapeutics.

Discussion

In this article, we disc

SUBMITTER: Bhagirath AY 

PROVIDER: S-EPMC5139081 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature