Identifying sensitive windows for prenatal particulate air pollution exposure and mitochondrial DNA content in cord blood.

ABSTRACT:

Introduction

Changes in mitochondrial DNA (mtDNA) can serve as a marker of cumulative oxidative stress (OS) due to the mitochondria's unique genome and relative lack of repair systems. In utero particulate matter ≤2.5μm (PM_2.5) exposure can enhance oxidative stress. Our objective was to identify sensitive windows to predict mtDNA damage experienced in the prenatal period due to PM_2.5 exposure using mtDNA content measured in cord blood.

Material and methods

Women affiliated with the Mexican social security system were recruited during pregnancy in the Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS) study. Mothers with cord blood collected at delivery and complete covariate data were included (n=456). Mothers' prenatal

SUBMITTER: Rosa MJ 

PROVIDER: S-EPMC5139686 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature