Does Timing of Colon Procedures Affect Outcomes in D-IBS Trials?

ABSTRACT:

Background

Sigmoidoscopy/colonoscopy is usually performed prior to enrollment into clinical trials of irritable bowel syndrome (IBS). Two main reasons are to rule out alternative diagnoses and to ensure that colitis is not present. However, the possible impact of a recent versus remote colon procedure on symptoms in IBS trials has not been evaluated. The aim of this study was to evaluate the effect of timing of colon procedures on symptoms in IBS trials.

Methods

Post hoc analyses were conducted using placebo patients with diarrhea-predominant IBS in a phase 2 trial. Pain, frequency, consistency, and urgency were analyzed using repeated measures models during the first 7 days of treatment and over the entire 12-week treatment period.

Results

Fifty-two placebo patients

SUBMITTER: Wang J 

PROVIDER: S-EPMC5139714 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature