Somatic Genomics and Clinical Features of Lung Adenocarcinoma: A Retrospective Study.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) is the most common histologic subtype of lung cancer and has a high risk of distant metastasis at every disease stage. We aimed to characterize the genomic landscape of LUAD and identify mutation signatures associated with tumor progression.

Methods and findings

We performed an integrative genomic analysis, incorporating whole exome sequencing (WES), determination of DNA copy number and DNA methylation, and transcriptome sequencing for 101 LUAD samples from the Environment And Genetics in Lung cancer Etiology (EAGLE) study. We detected driver genes by testing whether the nonsynonymous mutation rate was significantly higher than the background mutation rate and replicated our findings in public datasets with 724 samples. We performed subc

SUBMITTER: Shi J 

PROVIDER: S-EPMC5140047 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature