New learning while consolidating memory during sleep is actively blocked by a protein synthesis dependent process.

ABSTRACT: Brief experiences while a memory is consolidated may capture the consolidation, perhaps producing a maladaptive memory, or may interrupt the consolidation. Since consolidation occurs during sleep, even fleeting experiences when animals are awakened may produce maladaptive long-term memory, or may interrupt consolidation. In a learning paradigm affecting Aplysia feeding, when animals were trained after being awakened from sleep, interactions between new experiences and consolidation were prevented by blocking long-term memory arising from the new experiences. Inhibiting protein synthesis eliminated the block and allowed even a brief, generally ineffective training to produce long-term memory. Memory formation depended on consolidative proteins already expressed before training. After effect

SUBMITTER: Levy R 

PROVIDER: S-EPMC5140267 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature