Uptake and retention of manganese contrast agents for PET and MRI in the rodent brain.

ABSTRACT: Manganese-enhanced magnetic resonance imaging (MRI) is an established neuroimaging method for signal enhancement, tract tracing, and functional studies in rodents. Along with the increasing availability of combined positron emission tomography (PET) and MRI scanners, the recent development of the positron-emitting isotope ⁵² Mn has prompted interest in the use of Mn²⁺ as a dual-modality contrast agent. In this work, we characterized and compared the uptake of systemically delivered Mn²⁺ and radioactive ⁵² Mn²⁺ in the rat brain for MRI and PET, respectively. Additionally, we examined the biodistribution of two formulations of ⁵² Mn²⁺ in the rat. In MRI, maximum uptake was observed one day following delivery of the

SUBMITTER: Brunnquell CL 

PROVIDER: S-EPMC5140672 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature