Adenovirally-Induced Polyfunctional T Cells Do Not Necessarily Recognize the Infected Target: Lessons from a Phase I Trial of the AERAS-402 Vaccine.

ABSTRACT: The development of a vaccine for Mycobacterium tuberculosis (Mtb) has been impeded by the absence of correlates of protective immunity. One correlate would be the ability of cells induced by vaccination to recognize the Mtb-infected cell. AERAS-402 is a replication-deficient serotype 35 adenovirus containing DNA expressing a fusion protein of Mtb antigens 85A, 85B and TB10.4. We undertook a phase I double-blind, randomized placebo controlled trial of vaccination with AERAS-402 following BCG. Analysis of the vaccine-induced immune response revealed strong antigen-specific polyfunctional CD4⁺ and CD8⁺ T cell responses. However, analysis of the vaccine-induced CD8⁺ T cells revealed that in many instances these cells did not recognize the Mtb-infected cell. Our

SUBMITTER: Nyendak M 

PROVIDER: S-EPMC5141283 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature