Coding and decoding libraries of sequence-defined functional copolymers synthesized via photoligation.

ABSTRACT: Designing artificial macromolecules with absolute sequence order represents a considerable challenge. Here we report an advanced light-induced avenue to monodisperse sequence-defined functional linear macromolecules up to decamers via a unique photochemical approach. The versatility of the synthetic strategy-combining sequential and modular concepts-enables the synthesis of perfect macromolecules varying in chemical constitution and topology. Specific functions are placed at arbitrary positions along the chain via the successive addition of monomer units and blocks, leading to a library of functional homopolymers, alternating copolymers and block copolymers. The in-depth characterization of each sequence-defined chain confirms the precision nature of the macromolecules. Decoding of the fun

SUBMITTER: Zydziak N 

PROVIDER: S-EPMC5141382 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature