Progressive Muscle Cell Delivery as a Solution for Volumetric Muscle Defect Repair.

ABSTRACT: Reconstructing functional volumetric tissue in vivo following implantation remains a critical challenge facing cell-based approaches. Several pre-vascularization approaches have been developed to increase cell viability following implantation. Structural and functional restoration was achieved in a preclinical rodent tissue defect; however, the approach used in this model fails to repair larger (>mm) defects as observed in a clinical setting. We propose an effective cell delivery system utilizing appropriate vascularization at the site of cell implantation that results in volumetric and functional tissue reconstruction. Our method of multiple cell injections in a progressive manner yielded improved cell survival and formed volumetric muscle tissues in an ectopic muscle site. In addition, t

SUBMITTER: Kim JH 

PROVIDER: S-EPMC5141432 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature