Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells.

ABSTRACT: To fulfil the bioenergetic requirements for increased cell size and clonal expansion, activated T cells reprogramme their metabolic signatures from energetically quiescent to activated. However, the molecular mechanisms and essential components controlling metabolic reprogramming in T cells are not well understood. Here, we show that the mTORC1-PPARγ pathway is crucial for the fatty acid uptake programme in activated CD4⁺ T cells. This pathway is required for full activation and rapid proliferation of naive and memory CD4⁺ T cells. PPARγ directly binds and induces genes associated with fatty acid uptake in CD4⁺ T cells in both mice and humans. The PPARγ-dependent fatty acid uptake programme is critical for metabolic reprogramming. Thus, we provide important

SUBMITTER: Angela M 

PROVIDER: S-EPMC5141517 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature