Association of Increasing GFR with Change in Albuminuria in the General Population.

ABSTRACT:

Background and objectives

Hyperfiltration at the single-nephron level has been proposed as an early stage of kidney dysfunction of different origins. Evidence supporting this hypothesis in humans is lacking, because there is no method of measuring single-nephron GFR in humans. However, increased whole-kidney GFR in the same individual implies an increased single-nephron GFR, because the number of nephrons does not increase with age. We hypothesized that an increase in GFR would be associated with an increased albumin-to-creatinine ratio in a cohort of the general population.

Design, setting, participants, & measurements

We measured GFR by iohexol clearance at baseline in 2007-2009 and follow-up after 5.6 years in a representative sample of 1246 persons (aged 50-62 years) who

SUBMITTER: Melsom T 

PROVIDER: S-EPMC5142069 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature