Risk of Delayed Human Papillomavirus Vaccination in Inner-City Adolescent Women.

ABSTRACT:

Background

 Uptake of human papillomavirus (HPV) vaccine in the United States is slow, and the effectiveness of the vaccine has not been assessed in high-risk adolescent populations.

Methods

 We conducted a longitudinal study of 1139 sexually active, inner-city adolescent women receiving the 3-dose quadrivalent (4vHPV) vaccine. Cervical and anal specimens collected semiannually were tested using an L1-specific polymerase chain reaction assay. Postvaccination incidence of 4vHPV vaccine and nonvaccine HPV types, and risk of cervical cytological abnormalities, were assessed in relation to time to completion of all 3 vaccine doses.

Results

 Compared to vaccine naive women at enrollment, vaccinated women had significantly lower incidence rate ratios of cervical infection w

SUBMITTER: Schlecht NF 

PROVIDER: S-EPMC5142096 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature