Role of nitric oxide in the regulation of immune responses during rabies virus infection in mice.

ABSTRACT: Rabies virus (RABV) stimulates nitric oxide (NO) production, which either triggers T cell differentiation or suppresses T cell function depending on its concentration. Herein, we assessed the potential role of NO in regulation of immune responses during RABV infection in mice model. The experimental animals were divided into four groups and 100LD₅₀ of challenge virus standard (CVS) strain of RABV was inoculated intracerebrally on day 0 and subsequently aminoguanidine (AG; inducible nitric oxide synthase inhibitor) was injected intraperitoneally twice a day, up to 6 days. The samples were collected at 2, 4, 6, 8, 9, 10 and 12 days post infection (DPI). The immune cells including CD4⁺, CD8⁺ T lymphocytes and natural killer (NK) cells were estimated from perip

SUBMITTER: Madhu BP 

PROVIDER: S-EPMC5142598 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature