Expanded 3D Nanofiber Scaffolds: Cell Penetration, Neovascularization, and Host Response.

ABSTRACT: Herein, a robust method to fabricate expanded nanofiber scaffolds with controlled size and thickness using a customized mold during the modified gas-foaming process is reported. The expansion of nanofiber membranes is also simulated using a computational fluid model. Expanded nanofiber scaffolds implanted subcutaneously in rats show cellular infiltration, whereas non-expanded scaffolds only have surface cellular attachment. Compared to unexpanded nanofiber scaffolds, more CD68⁺ and CD163⁺ cells are observed within expanded scaffolds at all tested time points post-implantation. More CCR7⁺ cells appear within expanded scaffolds at week 8 post-implantation. In addition, new blood vessels are present within the expanded scaffolds at week 2. The formed multinucl

SUBMITTER: Jiang J 

PROVIDER: S-EPMC5143187 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature