MiR-135b, a key regulator of malignancy, is linked to poor prognosis in human myxoid liposarcoma.

ABSTRACT: Myxoid/round cell (RC) liposarcomas (MLS) were originally classified into two distinct populations based on histological differences; a myxoid component and a RC component. It is notable that, depending on an increase of the RC component, the prognosis significantly differs. Hence, the RC component is associated with metastasis and poor prognosis. However, the molecular mechanisms that contribute to the malignancy of the RC component still remain largely unknown. Here, we report microRNA-135b (miR-135b), a key regulator of the malignancy, highly expressed in the RC component and promoting MLS cell invasion in vitro and metastasis in vivo through the direct suppression of thrombospondin 2 (THBS2). Decreased THBS2 expression by miR-135b increases the total amount of matrix metalloproteinase

SUBMITTER: Nezu Y 

PROVIDER: S-EPMC5143367 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature