Strain-Dependent Recognition of a Unique Degradation Motif by ClpXP in Streptococcus mutans.

ABSTRACT: Streptococcus mutans, a dental pathogen, has a remarkable ability to cope with environmental stresses. Under stress conditions, cytoplasmic proteases play a major role in controlling the stability of regulatory proteins and preventing accumulation of damaged and misfolded proteins. ClpXP, a well-conserved cytoplasmic proteolytic system, is crucial in maintaining cellular homeostasis in bacteria. ClpX is primarily responsible for recognition of substrates and subsequent translocation of unfolded substrates into the ClpP proteolytic compartment for degradation. In Escherichia coli, ClpX recognizes distinct motifs present at the C-terminal end of target proteins. However, recognition sequences for ClpXP in other bacteria, including S. mutans, are not known. In this study,

SUBMITTER: Jana B 

PROVIDER: S-EPMC5143411 | biostudies-literature | 2016 Nov-Dec

REPOSITORIES: biostudies-literature