Cloning of the GABA_B Receptor Subunits B1 and B2 and their Expression in the Central Nervous System of the Adult Sea Lamprey.

ABSTRACT: In vertebrates, γ-aminobutyric acid (GABA) is the main inhibitory transmitter in the central nervous system (CNS) acting through ionotropic (GABA_A) and metabotropic (GABA_B) receptors. The GABA_B receptor produces a slow inhibition since it activates second messenger systems through the binding and activation of guanine nucleotide-binding proteins [G-protein-coupled receptors (GPCRs)]. Lampreys are a key reference to understand molecular evolution in vertebrates. The importance of the GABA_B receptor for the modulation of the circuits controlling locomotion and other behaviors has been shown in pharmacological/physiological studies in lampreys. However, there is no data about the sequence of the GABA_B subunits or their expression in the C

SUBMITTER: Romaus-Sanjurjo D 

PROVIDER: S-EPMC5143684 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature