CYP1A1, CYP2E1 and EPHX1 polymorphisms in sporadic colorectal neoplasms.

ABSTRACT:

Aim

To investigate the contribution of polymorphisms in the CYP1A1, CYP2E1 and EPHX1 genes on sporadic colorectal cancer (SCRC) risk.

Methods

Six hundred forty-one individuals (227 patients with SCRC and 400 controls) were enrolled in the study. The variables analyzed were age, gender, tobacco and alcohol consumption, and clinical and histopathological tumor parameters. The CYP1A1*2A, CYP1A1*2C CYP2E1*5B and CYP2E1*6 polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The EPHX1 Tyr113His, EPHX1 His139Arg and CYP1A1*2C polymorphisms were detected by real-time PCR. Chi-squared test and binary logistic regression were used in the statistical analysis.

SUBMITTER: Fernandes GM 

PROVIDER: S-EPMC5143764 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature