The known genetic loci for telomere length may be involved in the modification of telomeres length after birth.

ABSTRACT: Telomere length varies considerably among individuals. It is highly heritable and decreases with ageing or ageing related diseases. Recently, genome-wide association studies (GWAS) have identified several genetic loci associated with telomere length in adults. However, it is unclear whether these loci represent the genetic basis of telomere length or determine the individual susceptibility to shortening during growth process. Using DNA extracted from peripheral and cord blood of 444 mother-newborn pairs from a Chinese population, we measured relative telomere length (RTL) and genotyped eight known telomere length related variants that were initially identified in populations of European descent. We observed the T allele of rs10936599 and the T allele of rs2736100 were norminally associated

SUBMITTER: Weng Q 

PROVIDER: S-EPMC5143977 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature