Population-level impact and herd effects following human papillomavirus vaccination programmes: a systematic review and meta-analysis.

ABSTRACT:

Background

Human papillomavirus (HPV) vaccination programmes were first implemented in several countries worldwide in 2007. We did a systematic review and meta-analysis to assess the population-level consequences and herd effects after female HPV vaccination programmes, to verify whether or not the high efficacy reported in randomised controlled clinical trials are materialising in real-world situations.

Methods

We searched the Medline and Embase databases (between Jan 1, 2007 and Feb 28, 2014) and conference abstracts for time-trend studies that analysed changes, between the pre-vaccination and post-vaccination periods, in the incidence or prevalence of at least one HPV-related endpoint: HPV infection, anogenital warts, and high-grade cervical lesions. We used random-effect

SUBMITTER: Drolet M 

PROVIDER: S-EPMC5144106 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature